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KMID : 1149520200040020045
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Cardiovasclar Imaging Asia
2020 Volume.4 No. 2 p.45 ~ p.50
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Study Design and Rationale of Cardiac Computed Tomography Angiography and MRI in Patients with Type 2 Diabetes for Detection of Unrecognized Myocardial Scar in Subclinical Coronary Atherosclerosis (ACCREDIT Study)
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Kang Joon-Won
Ko Sung-Min
Choi Sang-Il
Choe Yeon-Hyeon
Choi Byoung-Wook
Lee Whal
Lim Tae-Hwan
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Abstract
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Objective: Cardiac computed tomography angiography (CCTA) allows the detection of subclinical coronary artery disease (CAD) CAD and delayed-enhancement cardiac magnetic resonance imaging (DE-CMR) enables the diagnosis of occult myocardial scar (OMS). The main objectives of the Assessment with CCTA and MRI in Asymptomatic Patients with Type 2 Diabetes for Detection of Unrecognized Myocardial Scar in Subclinical Coronary Atherosclerosis (ACCREDIT) study are to prospectively investigate the prevalence of OMS on DE-CMR images in asymptomatic patients with type 2 DM and to assess its correlation with subclinical CAD detected by CCTA.
Materials and Methods: This prospective, open-label, non-randomized, fixed-sequence and multicenter study aims to enroll 340 patients with type 2 DM and at least two identified cardiac risk factors, but without chest pain or history of coronary disease. CMR and CCTA examinations will be performed. Patient follow-up will take place over a 5-year period in order to assess the occurrence of major adverse cardiac events (MACE) and cardiac emergent significant diseases (ESD). The prevalence of OMS will be calculated based on the DE-CMR examination. For each main coronary artery, the degree of stenosis, plaque characteristics and the coronary artery calcium score will be determined by CCTA. The prognostic value of OMS on DE-CMR images and subclinical atherosclerosis detected by CCTA for occurrence of MACE and cardiac ESD will be assessed.
Conclusion: The ACCREDIT study will determine the prevalence of OMS and assess the prognostic value of OMS on DE-CMR images and subclinical CAD detected by CCTA in asymptomatic patients with type 2 DM.
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KEYWORD
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Myocardial infarction, Magnetic resonance imaging, Computed tomography angiography, Diabetes mellitus, Coronary artery disease
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